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10.1074/jbc.M011605200 J
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The molecular events leading to activation or silencing of glucose-sensitive neurons are surprisingly similar to those of the endocrine pancreas and include neuronal uptake of glucose via GLUT2, conversion to pyruvate (and finally ATP) via glucokinase, and modulation of neuronal firing mediated by changes in K ATP channel activity, cell depolarisation and Ca 2+ influx
Each of these addresses a specific concern that patients on GLP-1 therapy commonly experience
There, 70% of residents are either overweight or obese
Bottom Line This study is one of the more provocative breast oncology signals of the year
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